Muscle regeneration, aging and senescence

How metabolic state shapes repair, tissue loss and recovery.

We ask why muscle can rebuild after injury in one metabolic state yet fail in another. The current programme follows muscle stem-cell behaviour, the signals produced by senescent cells, and the mechanisms among them that could be translated into therapies for sarcopenia.

Differentiated human myoblasts stained for myosin heavy chain, with aligned myotubes in red and nuclei in blue

Differentiated human myoblasts stained for myosin heavy chain (MyH). Lab image.

Current directions

Publications from this area

Analysis of intracellular fatty acid metabolism during doxorubicin-induced senescence of MCF7 cells using Raman imaging

Pundlik SS, Venkateshvaran A, Suresh Y, Mamgain H, Ramanathan A. ACS Omega 2026;11(9):14426.

Dose-dependent effects of dihydronicotinamide riboside on human engineered skeletal muscle development

Venkateshvaran A, Pundlik SS, Suresh Y, Hegde A, Venkatesh B, et al. ACS Biomater Sci Eng 2026;12(7):3523–3538.

Integrative analysis of plasma small-molecule and gut-microbiome markers of sarcopenia in a pilot study within an Indian cohort

Hashmi MA, Verma S, Math RGH, Muralidharan S, Pranesh G, et al. Scientific Reports 2026;16(1):5602.

Pharmacological profiling of intravenous MP-04: sustained NAD+ augmentation, immune modulation, and renal protection in preclinical models

Ghosh A, Pranesh G, Zachariah N, Murakami E, Heredia A, Mathur P, et al. Frontiers in Pharmacology 2026;17:1832979.

Bulking up India’s healthy ageing strategy

Ramanathan A. Nature India. Comment. Published 23 July 2025.

Cold-shock proteome of myoblasts reveals role of RBM3 in promotion of mitochondrial metabolism and myoblast differentiation

Dey P, Rajalaxmi S, Saha P, Thakur PS, Hashmi MA, Lal H, Saini N, et al. Communications Biology 2024;7(1):515.

Senescent cells inhibit mouse myoblast differentiation via the SASP-lipid 15d-PGJ2 mediated modification and control of HRas

Pundlik SS, Barik A, Venkateshvaran A, Sahoo SS, Jaysingh MA, et al. eLife 2024;13:RP95229.

Aryl hydrocarbon receptor blocks aging-induced senescence in the liver and fibroblast cells

Nacarino-Palma A, Rico-Leo EM, Campisi J, Ramanathan A, et al. Aging (Albany NY) 2022;14(10):4281.

Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis

Wiley CD, Sharma R, Davis SS, Lopez-Dominguez JA, Mitchell KP, et al. Cell Metabolism 2021;33(6):1124–1136.e5.

Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis

Wiley CD, Brumwell AN, Davis SS, Jackson JR, Valdovinos A, Calhoun C, et al. JCI Insight 2019;4(24):e130056.

Mitochondrial dysfunction induces senescence with a distinct secretory phenotype

Wiley CD, Velarde MC, Lecot P, Liu SU, Sarnoski EA, Freund A, et al. Cell Metabolism 2016;23(2):303–314.

Carbon metabolism–mediated myogenic differentiation

Bracha AL, Ramanathan A, Huang S, Ingber DE, Schreiber SL. Nature Chemical Biology 2010;6(3):202–204.
No matching items