Ramanathan Lab
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Platforms

The experimental systems and measurements we share across every research area.

Our platforms let us follow a mechanism from the behaviour of single cells up to what a whole tissue can do. The same question can then be put to human tissue models, to cells under controlled environmental stress, and to quantitative functional and molecular measurement.

A whole bioengineered human muscle construct imaged with TMRM, showing mitochondrial membrane potential across the tissue

Bioengineered human muscle

Bioengineered human muscle provides a controlled tissue-scale system for investigating development, injury, repair and treatment response. The platform is being extended to motor neuron–muscle co-cultures and multiplexed models of sarcopenia.

We measure contractile force alongside quantitative imaging and molecular profiling, so that tissue architecture and metabolic state can be read against performance.

Explore the tissue-model work →

Gravisim

Gravisim is our ground-based microgravity simulation platform. It enables questions arising from spaceflight to be investigated through controlled, repeatable experiments with cells and bioengineered tissues. A patent has been filed for the Gravisim microgravity system.

See the microgravity programme →

Metabolomics and lipidomics

Discovery and targeted measurements across cells, tissues and biofluids show how metabolic state tracks with cell fate, environmental stress and treatment response.

View the platform record →

Raman chemical map of a single cell showing the spatial distribution of molecular signals

Raman imaging and image analysis

Label-free Raman maps and quantitative microscopy reveal spatial changes that bulk measurements can miss.

View the Raman work →

Raman map from Pundlik SS, Venkateshvaran A, Suresh Y, Mamgain H, Ramanathan A. ACS Omega 2026;11(9):14426.

Ramanathan Lab · inStem, GKVK Campus, Bellary Road, Bangalore 560065, India arvind@instem.res.in

Last updated September 2026

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